Active components in Bifidobacterium longum subsp. longum BB536 can effectively suppress the level of serum ovalbumin (OVA) and specific immunoglobulin E (IgE) levels. By modulating the IgG2a/IgG1 ratio, it can significantly reduce the recurrence of urticaria and shorten the duration of post-recurrence pruritus.

Bifidobacterium breve BR03 can increase the IFN-γ level in the peripheral blood of dermatitis patients, effectively suppress the production of the pro-inflammatory Th2 cytokine and IgE antibodies so as to reduce the frequency and severity of dermatitis.

Lacticaseibacillus rhamnosus GG can reduce the level of inflammatory cytokines such as TNF-α, IFN-γ, IL-5, and IL-10 so as to effectively enhance immunity, alleviate allergic reactions in the airways and bronchis to postpone the progression of asthma.

Bifidobacterium breve M-16V can promote the secretion of IFN-γ and IL-12 and suppress airway inflammation by regulating Th1 cytokines and IgE levels so as to effectively alleviate cough symptoms.

Lacticaseibacillus rhamnosus GG can alleviate symptoms such as itchy eyes, redness, and tearing by balancing the Th1/Th2 cell level, inhibiting degranulation of sensitized mast cells, and reducing the release of inflammatory mediators, so as to effectively lower the recurrence frequency of allergic conjunctivitis.

Lacticaseibacillus rhamnosus GG can inhibit allergen-induced local eosinophil infiltration and reduce the serum-specific IgE/IgG2a ratio so as to effectively alleviate symptoms such as sneezing, nasal congestion and rhinorrhea caused by allergic rhinitis.

Bifidobacterium animalis subsp. lactis BB-12 can significantly reduce the number of escherichia coli and bacteroides in the gut and improve various food allergy symptoms caused by ovalbumin by lowering the IL-4/IFN-γ ratio.

Bifidobacterium animalis subsp. lactis BB-12 and Lacticaseibacillus rhamnosus GG can reduce the recurrence of allergic symptoms by altering the sensitivity of allergen receptors (TLRs). Long-term consumption of them can effectively alleviate or even eliminate allergic symptoms.