Lactiplantibacillus plantarum LP45 can markedly reduce triglycerides, VLDL-cholesterol and C-reactive protein in human blood. By regulating systemic metabolism it modulates teh secretion of neurochemical substances, so as to ameliorate hypoxia-induced cognitive impairment.

Lactiplantibacillus plantarum LP45can reduce the expression of pro-inflammatory factors in the blood, colon and hippocampus of AD mice by decreasing the abundance of Bacteroides, and increasing the abundance of Acetoin bacteria and Chlorella so as to improve the spatial memory impairment of AD patients.

Bifidobacterium longum subsp. longum BB536 can lower resting plasma corticosterone and decrease the kynurenine-to-tryptophan ratio, so as to dampen stress responses and mitigate psychiatric symptoms.

L-Theanine can stimulate the generation of alpha waves in the brain. By down-regulating the expression of GAT-1 protein in neurons and glial cells, it can effectively improve the sleep efficiency of patients with insomnia and help them achieve deeper sleep and prolong sleep duration.

Lacticaseibacillus paracasei NTU 101 can activate the enteric nervous system and attenuate neuro-inflammation by suppressing vascular risk factors and hippocampal matrix metallopeptidase activity, so as to safeguard brain neurons

L-theanine can lower brain levels of dopamine, norepinephrine, corticosterone and serotonin, while boosting α-waves and diminishing β-waves, so as to enhance stress resilience and alleviate mental fatigue.

Weizmannia coagulans MTCC 5856 can produce the short-chain fatty acids like acetate, propionate and butyrate, and greatly reduce TNF-α in peripheral blood and IFN-γ, TNF-α and IDO1 in hippocampus, so as to effectively ease anxiety, depression and other negative moods.