Bifidobacterium animalis subsp. lactis HN019 and Lacticaseibacillus rhamnosus HN001 can effectively activate gut immune cells to produce biochemical signaling molecules that direct macrophages to rapidly recognize and kill enteric pathogens, so as to rebuild the body's immune barrier.

Supplementation with Lacticaseibacillus rhamnosus CRL1505 can effectively activate peroxisome proliferator-activated receptor α (PPAR-α) and up-regulate the expression of immune genes such as IFN-α and IFN-β, so as to enhance resistance to viral invasion and preventing infection.

Lacticaseibacillus rhamnosus GG can greatly elevate serum IL-12 levels and promot the generation of natural killer cells and cytotoxic T lymphocytes, so as to enhance the body's capacity to eliminate aberrant or infected cells.

Lacticaseibacillus rhamnosus GG can raise the systemic proportion of short-chain fatty acids, so as to effectively suppress the production of osteoclastogenic cytokines in bone marrow, spleen, and intestine, which helps to prevent and mitigate bone loss.

Weizmannia coagulans GBI-30 can remarkably lower levels of the pro-inflammatory cytokines TNF-α, IL-6 and IL-12 in serum, and relieve inflammatory joint responses in RA patients by modulating the Th17/Treg ratio in the spleen,so as to relieve joint pain.

Bifidobacterium breve BR03 BR03 can improve muscle damage by reducing the level of IL-6 in the circulation and the concentration of creatine kinase in the body so as to effectively accelerate the recovery speed of muscle fatigue after traumatic exercise.

Lactiplantibacillus plantarum 299V can produce SOD, GSH-Px, CAT and other highly antioxidative metabolites which can greatly attenuate systemic oxidative-stress damage, so as to help to slow the aging process.

Bifidobacterium animalis subsp. lactis HN019 can significantly elevate levels of vitamin B1, zinc, total free fatty acids, linoleic acid, arachidonic acid and DHA in human bodies, so as to promote more efficient nutrient uptake.

Bifidobacterium animalis subsp. lactis HN019 can greatly increase the level of IL-2, ferritin (SF), and serum iron (SI) levels in human bodies so as to improve anemia and concurrently promote recovery of nutritional status and immune function in anemic individuals.